He had never pooped in the house and now he does every time he has to be put in his indoor pen for us to leave or sleep. Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. What Are The Side Effects Of Simparica Trio For Dogs? Other alternative drugs are likely to offer poorer protection. Stopped meds and he has had 3 more seizures since. Now we are waiting for the verdict: whether its an infection in his bladder or stones. He is back to his old self now but we will never give him this medication again. She is only 6 and was so full of life and energy. However, they are possible, so it is better to know they might happen. Hoping for a good outcome!!! Now do you get the connection? And now I'm upset with myself for giving this to my dog without doing research. How can it not be the Simparica that did this to my baby when nothing else changed. Simparica is approved for dogs and puppies weighing more than 2.8 pounds and over 6 months of age. I couldnt figure it out until I googled all the medications the vet has prescribed for her then I came across this forum and I am pissed!! (147 Reviews) $18.38 - $44.91. He has been low energy since. It's 5:53pm and he's acting very lethargic. How did your baby do please? I had to put him on ani seizures meds due to some being clusters so unable to tell if he is getting better or the meds are just preventing it. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Just wanted to share my experience in case anyone else has similar experience with dog's character changing. Our dog has had 2 Seizures this month and we are going to stop using Simparica. Doctor prescribed the salyien with some injunction but all are in vain..my labrador has same issues till datemy vet.not says anything about the side effect of the Simparica..i m now helpless..pls help me what should I do.. please help me to rid over itpls pls ..guide me. When I bathe him the scabs fall off and I think, oh good, this problem is going away. She is lethargic, unsteady on her feet, doesnt bark at all, showing signs of dimentia. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. . In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. I just want to cry! Decreased conscious proprioception. Did you ever do an MRI or spinal tap? Side effects of Simparica Let us now look at possible side effects when administering Simparica. Im wondering if there is any correlation as we havent changed anything else with him. It really helped us to put this diarrhea condition in perspective. My last one lived to almost 15yrs old and I truly believe it was because I had him on Springtime Garlic tabs. Hi i have only had my pup for about a week and a half i took him to vet and asked what would be safe to use since my pup is only about 11weeks old and weighs 4pds (prob less today) i gave him this medicine last nite and wish i would have seen this post sooner Now i pray he makes it thru the night. I'm so angry this medication is on the market. She has episodes where she seems very anxious and is hiding under car/tables/beds. I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. Not known if there be permanent after-effects. old . I went to zoetis and Expressed my views and they said the FDA report meant nothing and it was in America. He is still not himself, walks very slowly and is definitely not feeling his best. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders. It's getting better and I decided to just wait and hope when this stuff clears out in 30 days he goes back to normal. I hope these steps will prevent anyone else's pet having to endure this. I could never forgive myself. There was no clear diagnosis but it was clearly neurological. I thought it was just her aging but now I think it al started when she started this medication. Bella continues to drink in excess of normal amounts. Simparica chewable is a preventative that is better suited to healthy adult dogs living in areas where ticks are prevalent. Still waiting on the vet and waiting to talk to ASPCA poison control. Meaning he is suppose to get it today. Thank you! Our two shih tzus are 6.5. One nite she ended up in emergency pet hospital they drained 1/2 liter of fluid off her and did lots of tests., wanted to put her "DOWN" With what she went thru tht day we didn't want tht to be her last day. I am both incredibly sad and angry. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. If she comes out of this I will return to heartworm pills and topical flea and tick meds. My beautiful boxer lost his appetite after just one dose of Simparica. On 01/07/21, we gave our 11 year old black lab, Rawley, a 2nd dose of Simparico TRIO. All antiparasitics for dogs lower the seizure threshold. She has been diagnosed with thyroid problems and myocarditis. Is your puppy better now and how long did his symptoms last for? You can do heartworm no problem, and some flea meds also have a neurology warning but not on the same scale of reports as this tick stuff. Pyrantel Pamoate was first approved in 1977 for the treatment and . Hello! About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. Hi, I was just wondering how long you continued on with the steroids with your puppy. On Friday he was incredibly thirsty - he would drink a full bowl of water and then look at me for more. Duke is 7 month boxer And we have the simpatica on Monday and cant believe this stools Hopefully it doesnt last long. . I called the vet and they said it was likely brought on by stress. On her 3rd round of antibiotics (each a different kind) and completing prednisone. Please do NOT try Simparica Trio, I went to the Vets office to pick up Dukes Revolution Heart Worm meds, and they talked me into switching to Simparica Trio, we gave Duke his first dosage on March 1st, March 2nd, he would fall down while walking, he would fall down trying to get up, he's NEVER done this before! I am interested in the petition and the company's response. We rushed him to the emergency vet and they put him on keppra to stop the seizures. Revolution has been around decades with less incidents of animal reactions. Gave our 23 month old Black Lab. I am convinced this medicine is HORRIBLE and is causing this. All said, we are over $8K into vet bills and growing, Given that he had no noted medical issues prior, his vet and the urgent care vet both feel is was likely the Simparico. Don't trust your vet, do your own research. Simparicaworks by impacting the nervous system of invertebrates such as fleas and ticks. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Random vomitting is no fun either. Called vet and was advised chicken and rice by tech - vet did not come to the phone even tho I asked to speak to her twice. RELATED: Signs Your Dog Might Be Having a Seizure. He is stumbling, not able to stand on tile or go in and out of house without tripping on steps. We go for more bloodwork today and are praying for better news. iI hope she will not have any other problems. She keeps running through the house as though looking for something. Our new vet has recommended Simperica, but I wont be giving it to my Collie. I am terrified--wish I would of seen this sooner. I do know that she was a healthy and somewhat energetic 10 year old before the treatment. We have given him pedialyte. If these symptoms appear on your pet, do not worry, it is normal after taking a dose of Simparica. Some reports showed the dogs could have simparica seizures. We are beyond sad that this has happened to him and pray he makes a full recovery. Them I took him to a vet for check up and to my horror, he has fleas and a tick. Our vet recommended putting him on phenobarbital. And has been for about 3 weeks. I have a person that bought a husky puppy from me March 6 @ 6 weeks old. Did anyone see any signs of improvement in their dogs? That is the only thing that has changed in her routine. Ticks are horrible here in Maine. Mine is due for another dose next week and I don't know what to do. In a weak moment last week she prescribed Simparica for a flea problem my 5 year old Springer was having. They immediately denied they were in the wrong for prescribing because any meds can have side effects but Im convinced this medication is poison. Im trying to understand how. But im 99% sure the simparica is what caused it. But today, after he ate dinner and drank water, it all came back up. This medication works within the first few hours after administration to kill fleas present on your dog, and is dosed by weight, so it is important to use the correct-sized medication for your pet. I bought chicken last night he ate some of that . No simparica for them either! He is fully housebroken and just had a running stool accident in the house. After reading all these posts that sound so similar to what we are going through. The personality change is what has me most concerned too. I had a trainer come in the day of, and he was with me the all day, NOTHING a happened for him to be in pain! It's now March 23, he still has falls but not like at first. Is it too late? just gave my one year old dauchund her first dose of simparica My vet didnt tell me, We gave our Yorkie this and she went into seizures later in the daywhat if any thing can be done. So the next day was Saturday , me & my husband got up early . Other adverse reactions like lethargy, anorexia, itching, and increased thirst are possible but not very likely. After about 35 days he was back to normal. Simparica may also cause the following side effects: Vomiting Diarrhea Lethargy Contact your veterinarian if your dog experiences any side effects as a result of taking Simparica. He would come out of it when I shook him, so I didn't think anything of it at the time. around 12 years She grabs and won't let go. 5 hours after the dose she's home resting. I PRAY that our baby is okay with this second dose. Never ever again with this med for him. 24 hours after, we noticed diarrhea. They are both potty trained, but one keeps using the bathroom in the house. Those with Diarrhea symptom, did it look like mucus in their pets stool? Took her to her Vet where I was told she had another tremor. I have been telling everyone not to give this to their furry ones!!!!!!!! Not grass grazing either. She has been very unpredictable and snapping at people but this is improving. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. How is your dog doing at this time? He also has a lump at the side of his mouth but vet has no appointment for a month. Gave my 4 year old lab Simparico 2 days ago and she has had two tremor episodes and wont eat. I called the vet and she gave me anitdiarrhea medicine. He is eating fine with no diarrhea or vomiting. I am going to try stopping the medication for a month to see if things improve. In general dogs tolerate very well sarolaner at the therapeutic dose range (2 to 4 mg/kg). I sure hope he makes it! I gave my dog simparica trio. Bella is very consistent and normally has two bowel movements but hubby noted an increase in bowel movements and their amounts. Really? I'm so sorry. She hasnt eaten in 3 days and is unable to go up 2 simple steps. As per the vet, Simparica is an excellent flea and tick product that is available in oral form. The Simparica was recommended by the vet. My dog is currently in an emergency hospital in Chicago with my daughter. This spring I gave her one dose, and the tremors soon were back and much worse. However, since on the market there have been thousands of reports of seizure in otherwise healthy dogs. Do not give extra or double doses. My 3 month old shih tux Juno took her second dose last week and for the last two days shes vomited and has been eating grass nonstop! My vet recommended Simparica Trio for both my dogs (13 year old healthy Collie mix 7 lb chihuahua mix). You seem like an idiot. Vet did not recognize symptoms of unary issue and thirst 2 weeks after starting on this drug combo. I feel so sad for you Camelia. For dogs with a history of seizures: consider carefully. He is not the same puppy prior to two days ago! I thought maybe it was just a allergy break out which she's never had this long now I'm wondering if she's continuing to have a reaction. 10 days after taking Simparica, she started having muscle tremors. That sh-t should be banned. I will update once we have results from diagnostics. I will use Sentinel and Pet Armor on her as this is what I have always gjven my dogs with no problems. No more of this junk for my pups! Friday early evening Bellas stool was still soft with structure with the outside color almost black but the inside was tinged with lime green. Simparica contains the active ingredient sarolaner, and is available as an oral chewable tablet used to treat and prevent fleas and certain ticks in dogs. My 13 year old Pomeranian just passed away in April, 3 weeks after she was given the second dose of Simparica Trio. They both got similar issues and this was the only thing they both did. I am starting to get scared they are both 80 lbs and the other dog is. Not wanting to play, shivering, and drinking excessively. Was not too excited about it, and I really should've declined it. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. Same thing has happened to my 5 month old puppy after taking simparica. My dog died from it after one dose within 24 hours. Gave my 14 month old 88 lb. Side effects are rare and may include: Vomiting Lethargy Diarrhea Loss of appetite Neurologic side effects have been seen after using medications in this class of drugs. Also - do NOT use Bravecto for females you intend to breed. Sometimes I think he is either blind or deaf. I will be speaking to vet to switch to something else. Advised I could call Simparica for reimbursement or to report side effects. We gave Simparica two days ago and he's not had an appetite, he's eating grass, is drinking a lot of water and sleeping. It comes as the first choice when prescribing a treatment due to its liver flavor. The doctor did blood work and gave him steroids and said to watch him carefully for the next few days. My other two dogs had a little loose stool but nothing else. The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). Animal Drug Safety Communication: FDA Alerts Pet Owners and Veterinarians About Potential for Neurologic Adverse Events Associated with Certain Flea and Tick Products, How to Report Problems with Flea and Tick Products, An official website of the United States government, : Get the dog moms and dads in your life something unique this year. How long did it last with your dog? Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . We gave our one year old Simparica tonight and he started having trimmers that lasted on and off for about 30 minutes. In very rare instances, mild side effects and irritations can occur for a short period of time. No problem eating. Next day, he was suddenly 1000% worse, would not touch food, could not move. For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. Vet put her on metronidazole which is working. I don't recommend anyone risk their pet's life just to be a little easier having a pill to take. Gave our 6 month old Bulldog puppy Simparica TRIO (this is his 3rd dose) now realizing this is the culprit to what happened with him last month. So sorry! She seems more anxious now and really attached to hubby. Moxidectin stops heartworm . Company asked us to do diagnostic testing at vet. Simparica Trio is intended for dogs and puppies weighing more than 2.8 pounds and older than 8 weeks of age. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. Things like: tremors decreased conscious proprioception ataxia reduced or absent menace, and or seizures Simparica is not recommended in lactating, pregnant females, or dogs used for breeding. . What number do we call for FDA? Im switching back to the old stuff. I knew it was bad from the onset but the vet said I can't take a chance on him getting heartworms because the mosquitos are so bad not to mention fleas and ticks. He is also running a fever so is not out of the woods. What should I do? My dog is having the same issues. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. Simparica and Simparica Trio are available by prescription only. Simparica has possibly shown no severe side effects that may concern the health of dogs. Im wondering if anyone else has seen these types of symptoms. For those who lost their dear companions from this medicine my heart goes out to you all. If you accidentally ingest a pet medication, call your physician or the national Poison Control Center hotline at 800-222-1222. The reaction lasted less than 12 hours. In addition to the tremors, have you noticed any . I called the vet and am putting him back on Heartgard and Nexgard. Glad i held off on the free sample i was given! My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. Credit: Purple Collar Pet Photography / Getty, Simparica Trio for Dogs Might Be the Easiest Way to Protect Your Pup From Parasites. These are classic neurological symptoms, exactly what our Pickles had before she passed. Nothing they can do for her she said. The seizure has finally stopped and he seems to be sleeping peacefully. I have paid about $500 - $600 to heal the little King, but it's not working. I lost my previous bichon poo to seizures 2 years ago and I dont want to go through that type of pain and lost again! This is terrible. In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. Maybe? By the following day, she was showing symptoms of marked neurological impairment, similar to a human having suffered a stroke. Sound familiar? Im wondering if after it is out of his system or have I now poisoned my baby where he might have a seizure disorder for the rest of his life. $37.98 with Subscribe & Save discount. I feel the manufacturer should pay my test bills and meds .. my doc talked me into this regimine of meds and my previous dog did well on sorresto color and heart word med .. any clue on who I contact ? It is Now 3 pm and Lily is on her way to the animal hospital and most likely going to have to spend the night, we will flush her with iv and hope It helps Flush It out Of her system. Thursday morning was an awful beginning of the day for our boy. This time I am seeing a little blood or tissue in her stool. She uses drops 4 times a year on the top of the neck for fleas etc and told me to address the heart worm problem with the vet. If this was our children and you went to your doctor for a shot, and the Dr. said "don't worry, only 1% of kids get seizures or other problems from this shot, we wouldn't stand for it. Hoping you are the lucky ones!! I will be changing clinics immediately. I shall be looking for a natural product from now on, k and g pet supplies on amazon do a good mange spray so hopefully that will be all they need from now on. All the swelling went down immediately and the itching went away too. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. I have ordered what I normally use and will throw this in the trash! Like other oral treatments, Simparicaworks by entering a dogs bloodstream immediately after ingestion. I came across this site and read so much about symptoms that I now realize he has been having. So sorry to hear, and good for you in recognizing the problem! He has been dribbling pee and no longer has a stream and for obvious reasons is asking to go out way more often than his usual. Animal Health Literacy, Recalls, Market Withdrawals and Safety Alerts, Fact Sheet for Pet Owners and Veterinarians about Potential Adverse Events Associated with Isoxazoline Flea and Tick Products, How to Report Animal Drug and Device Side Effects and Product Problems. 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